The synthesis, study of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridyn-3-yl)-(alkyl, heteryl)methanimines and their derivatives

mixture from 6-(5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-amine and aldehydes. The synthesis was carried out in the acetic acid medium. The mixture was kept at room temperature for 6 h. 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines were reduced in the 1,4-di-oxane medium. As a reducing agent sodium borohydride was used. Results and discussion. As a result of synthetic transformations 17 new compounds have been obtained, the structure of the compounds synthesized has been confirmed by modern complex of physicochemical methods of analysis (IR-spectrophotometry, elemental analysis), and their individuality has been proven on an Agilent 1260 Infinity HPLC high-performance liquid chromatograph equipped with an Agilent 6120 mass spectrometer. Conclusions. The preparative method for the synthesis of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines and 6-(5-phenethyl-4-R-1,2,4-triazole-3-ylthio)-N-(alkyl-, heteryl)pyridine-3-amines has been developed.

Выводы.Разработан препаративный метод синтеза 6- Ключевые слова: 1,2,4-триазол; пиридин; синтез; физико-химические свойства In the pharmaceutical practice directly related to the search of biological active substances and their introduction into medicine or veterinary it is generally recognized that a successful choice of the research object is a prerequisite for a positive final outcome to create original effective and low-toxic drugs.It should be noted that compounds containing 1,2,4triazole core may be interesting not only for synthetic chemists, but also for pharmacists, physiologists and other scientists [1][2][3][4].
During the past decade the literature constantly showed the instance of studying the properties of these heterocyclic compounds [5][6][7].At present, derivatives of 1,2,4-triazoles containing pyridine deserve special attention.Such compounds are the subject of attention of various research activities.The systematization of information on the research results for derivatives of 1,2,4-triazoles is absent.
That is why the synthesis and study of physicochemical properties of new compounds, which contain 1,2,4-triazole and pyridine rings, are important tasks of modern synthetic and pharmaceutical chemistry.

6-(5-Phenethyl
IR-spectra were registered for pellets of potassium bromide using a SPECORD 200 spectrophotometer in the range of frequencies of 4000-500 cm -1 (scanning conditions: the target program 3.0, the time constant τ was 3 sec, the scanning time was 33 min).Pellets were prepared using combined grinding of 200 mg of potassium bromide and 2 mg of the compound studied with further pressing [8][9][10].
The purity and molecular weight of the new compounds synthesized were determined using the method of high performance liquid chromatography.The chromatography-mass spectrometry studies were conducted on an Agilent 1260 Infinity HPLC liquid chromatograph equipped with an Agilent 6120 mass spectrometer (in electrospray ionization (ESI)) [10].
The structure of new compounds obtained was confirmed by the complex application of the elemental analysis and IR-spectrophotometry. Individuality of these substances was proven by the method of HPLC/DAD-MS.Some of the physicochemical properties are shown in Tab. 1, 2 and 3.The results of the elemental composition determination indicate that the experimental data do not differ from the theoretical ones by more than 0.25 %.
It was found by the method of HPLC/DAD-MS that the higher was the yield of the compound synthesized the cleaner it was.
2. The structure, individuality and physical and chemical constants have been determined for all compounds synthesized using modern methods of physical and chemical analysis.
Conflict of interests: authors have no conflict of interests to declare.