DOI: https://doi.org/10.24959/ophcj.13.742

One-pot synthesis of the substituted imidazolidin-2-ones with participation of thiobarbituric acid, ureas and arylglyoxals

N. M. Kolos, L. L. Zamigaylo, N. V. Chechina

Abstract


Derivatives of imidozoline-2-ones containing the pyrimidinthionic moiety in position 4 have been synthesized by three-component one-pot condensation of thiobarbituric acid, arylglyoxal hydrates and ureas. It has been found that these compounds exist in the solution of DMSO-d6 as a mixture of two tautomeric forms: for products obtained from N-substituted ureas the imidazolidin form predominates; and in the case of urea the imidazolidin and imidazolin forms are present in the ratio of 1:1.


Keywords


imidozoline-2-ones; one-pot synthesis; tautomerism; thiobarbituric acid; arylglyoxals; ureas

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Abbreviated key title: Ž. org. farm. hìm.

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