A new method for synthesis of atomoxetine and its interaction with with azole-con¬taining sulfonyl chlorides

Authors

  • M. K. Korsakov Yaroslavl State Pedagogical University. KDUshinsky, Russian Federation
  • L. O. Shumilova Yaroslavl State Pedagogical University. KDUshinsky, Russian Federation
  • V. O. Postnov Yaroslavl State Pedagogical University. KDUshinsky, Russian Federation
  • M. V. Dorogov Yaroslavl State Pedagogical University. KDUshinsky, Russian Federation
  • M. Yu. Solovyov Yaroslavl State Pedagogical University. KDUshinsky, Russian Federation

DOI:

https://doi.org/10.24959/ophcj.13.765

Keywords:

atomoxetine, enzymatic catalysis, carbonyl reductase, sulfonyl chloride, sulfonamide

Abstract

A new approach to the synthesis of atomoxetine using the methods of enzymatic catalysis has been developed;
the interaction of atomoxetine with a number of azole-containing heterocyclic sulfochlorides has been studied. The
carbonyl group of 3-chloro-1-phenyl-propane-1-one was region-specifically reduced with NADPH-dependent
carbonylreductase (SSCR) in phosphate buffer solution. In Mitsunoby reaction with o-methylphenole the inversion
of the final product configuration takes place and [R]-1-(3-chloro-1-phenypropoxy)-2-methylbenzene is formed.
Its further treatment with methylamine results in the base of atomoxetine, which may be isolated from the solution
as a chloride. In order to develop the novel biologically active compounds the series of sufonyl chlorides with
oxazole and isoxazole substituents were reacted with atomoxetine. The sulfonamides obtained fully comply with
all criteria for the molecules – candidates for the biomedical study.

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References

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Published

2013-12-02

How to Cite

(1)
Korsakov, M. K.; Shumilova, L. O.; Postnov, V. O.; Dorogov, M. V.; Solovyov, M. Y. A New Method for Synthesis of Atomoxetine and Its Interaction With With Azole-con¬taining Sulfonyl Chlorides. J. Org. Pharm. Chem. 2013, 11, 38-41.

Issue

Vol. 11 No. 4(44) (2013)

Section

Original Researches

License

Copyright (c) 2013 National University of Pharmacy

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