Methods of synthesis and properties of thiazolopyridines


  • T. I. Chaban Lviv National Medical University named after Danylo Halytsky, Ukraine



thiazolopyridine, synthesis, properties, condensed, pharmacological activity



The review systematizes the theoretical and experimental data concerning methods of synthesis of condensed thiazolopyridines, which at present have been insufficiently studied, the prospects for their application in the directed synthesis of new physiologically active substances. The recent developments in their pharmacology have been also analyzed. The available methods for the synthesis of condensed thiazolopyridines can be divided into two fundamentally different approaches. The first approach is based on annelation of the thiazolidine or thiazole cycle to the pyridine ring, and the second one use pyridine derivatives as starting materials; their functional groups make it possible to change the pyridine ring. Methods for obtaining thiazolopyridines using solid media carriers, and their synthesis with domino reactions deserve a particular attention. Generalization of the scientific data published confirms that the condensed thiazolopyridines exhibit various biological effects. In particular, they are characterized by analgesic, anti-inflammatory, antimicrobial, antioxidant and antifungal activities. Due to the inhibitory action on integrally linked kinase the specified class of compounds can eliminate the hyperproliferative disorders in the living organisms. It has been found that these derivatives exhibit the antidiabetic, antibacterial and anti-tuberculosis action. It is known that derivatives of thiazolopyridines have shown a positive effect in the treatment of sexual dysfunction. Thiazolopyridine derivatives containing the α-amino phosphonate residue at 2 position of the basic heterocycle exhibit a significant anticancer effect.


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How to Cite

Chaban, T. I. Methods of Synthesis and Properties of Thiazolopyridines. J. Org. Pharm. Chem. 2015, 13, 8-19.



Original Researches