TY - JOUR AU - Karpova, Svetlana P. AU - Ivashura, Maryna M. AU - Koval, Alla O. AU - Kolisnyk, Yulia S. PY - 2023/08/30 Y2 - 2024/03/29 TI - The Quantitative Determination of Oxacillin Using Kinetiс-Spectrophotometric and Redox Titration Methods JF - Journal of Organic and Pharmaceutical Chemistry JA - J. Org. Pharm. Chem. VL - 21 IS - 2 SE - Original Researches DO - 10.24959/ophcj.23.273654 UR - https://ophcj.nuph.edu.ua/article/view/273654 SP - 15-20 AB - <p>The search for new analytical reactions and finding out the optimal conditions for their course, which can be used as the basis for quantitative analytical determinations of penicillins, is a very urgent task.<br /><strong>Aim</strong>. To develop methods for the quantitative determination of Oxacillin.<br /><strong>Materials and methods</strong>. The study object was Oxacillin sodium salt powder in vials for preparing a solution for injections<br />(0.5 g). Peroxomonosulfate acid as triple potassium salt 2КНSO<sub>5</sub>∙КНSO<sub>4</sub>∙K<sub>2</sub>SO<sub>4</sub> (Oxone<sup>®</sup>) of “extra pure” grade was used as an oxidant. The methods of kinetic spectriphotometry and redox titration were used.<br /><strong>Results and discussion</strong>. A simple procedure for the quantitative determination of the Oxacillin pure substance by the kinetic spectrophotometry and redox titration methods using potassium hydrogen peroxomonosulfate (KHSO<sub>5</sub>) has been developed. The results of the drug analysis obtained by newly developed and current methods are in good agreement with each other; <em>δ</em> (correctness) = (0.45 – 0.86) %.<br /><strong>Conclusions</strong>. Using the methods of kinetic spectrophotometric and redox titration, two independent procedures for the<br />quantitative determination of oxacillin in the substance and the drug product have been developed using potassium hydrogen peroxomonosulfate as an analytical reagent (KHSO<sub>5</sub>). A relative standard deviation RSD = (1.24 – 2.17) %.</p> ER -