TY - JOUR AU - Mykhailenko, O. O. AU - Kovalyov, V. M. AU - Kovalyov, S. V. AU - Krechun, A. V. PY - 2016/12/16 Y2 - 2024/03/28 TI - Biologically active compounds from the rhizomes of iris hungarica JF - Journal of Organic and Pharmaceutical Chemistry JA - J. Org. Pharm. Chem. VL - 14 IS - 4(56) SE - Original Researches DO - 10.24959/ophcj.16.903 UR - https://ophcj.nuph.edu.ua/article/view/ophcj.16.903 SP - 63-66 AB - <p><em>Species of Iris genus (Iridaceae) have a long history of traditional medicinal use in different countries as alternative</em><em> </em><em>aperient, tonic, cathartic, diuretic, gall bladder diseases, liver complaints, dropsy, purification of blood,</em><em> </em><em>venereal infections, fever, bilious infections and for a variety of heart diseases. The rhizomes of Iris are the rich</em><em> </em><em>source of the secondary metabolites, in which flavonoids predominate. The clinical studies of substances from</em><em> </em><em>irises gave positive results in the treatment of cancer, bacterial and viral infections. Continuing the search of new</em><em> </em><em>biologically active compounds from the plants of Iridaceae family for the first time three isoflavones that are new</em><em> </em><em>for this species – irigenin, iristectorigenin B and its glucoside iristectorin B have been isolated from the ethanolic</em><em> </em><em>extract of the rhizomes of Iris hungarica Waldst. et Kit., which is widespread in Ukraine. The structure of the compounds</em><em> </em><em>is described as 5,7,3’-trihydroxy-6,4’,5’-trimethoxyisoflavone, 5,7,4’-trihydroxy-6,3’-dimethoxyisoflavone</em><em> </em><em>and iristectorigenin B-7-O-β-D-glucoside, respectively. The compounds were obtained from the ethyl acetate</em><em> </em><em>fraction of the iris rhizomes by column chromatography on silica gel with sequential elution of the chloroform –</em><em> </em><em>ethanol solvent with different concentrations. The structure of the compounds has been determined by chemical</em><em> </em><em>and spectral methods and in comparison with the literature data.</em></p> ER -