Synthesis and the study of physical and chemical properties of 2-((5-(phenoxymethyl)-4-R-1,2,4-triazole-3-yl)thio)ethan-1-ols and their derivatives

Abstract

The number of new various diseases increases with the development of science and technology. But currently medicine does not have effective ways to overcome this problem. There is a large number of different pharmacological groups of drugs at the pharmaceutical market, but some of them are not available for the Ukrainian consumers. Therefore, the main task of national scientists in the field of pharmaceutical synthesis is the search for new biologically active substances and their further introduction into medical practice as new, low-toxic, original medicines of the Ukrainian production at an affordable price. The aim of our research is the synthesis of a new class of biologically active substances, namely 2-((5-(phenoxymethyl)-4-R-1,2,4-triazol-3-yl)thio)ethan-1- ols and their derivatives. All compounds obtained have been synthesized from 5-(phen-oxymethyl)-4-R-1,2,4- triazol-3-thiones (R = H, C₂H₅, C₆H₅) using electrophilic and nucleophilic substitution reactions when heating. The structure of the compounds synthesized has been confirmed by using a modern set of physical and chemical methods such as IR-spectrometry, ¹H NMR spectrometry and elemental analysis, and their individuality by high performance liquid chromatography-mass spectrometry. The work in determining the parameters of acute toxicity and biological activity is continued.