The synthesis, computer prediction of the biological activity and the acute toxicity of 1-Ar-4-R-[1,2,4]triazolo[4,3-a] quinazolin-5(4H)-ones

S. Yu. Danylchenko, O. G. Drushlyak, S. M. Kovalenko


Using the PASS programme computer prediction of the biological activity of 1-Ar-4-R-[1,2,4]triazolo[4,3-a] quinazolin-5(4H)-ones has been performed; it has allowed to identify the types of the biological activity of the compounds studied and sort out the most promising compounds 5{1-20} with the potential anti-asthmatic and anti-allergic activity. Prediction of the acute toxicity of 1-Ar-4-R-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones 5{1-20} has been carried out by the GUSAR software, which allows to refer them to slightly toxic (toxicity class 4) or practically nontoxic (toxicity class 5) substances. The synthesis of the most promising compounds 5{1-20} studied іn silico for the biological activity and the acute toxicity has been conducted by interaction of the corresponding 2-hydrazinoquinazolin-4(3H)-ones 1{1-5} with imidazolides 3{1, 2} of aromatic acids 2{1, 2}, or with aromatic aldehydes 4{1, 2} followed by oxidation in the presence of FeCl3. The structure of the compounds 5{1-20}synthesized has been proven by the data of the elemental analysis and 1H NMR spectroscopy. The compounds obtained are promising objects for further investigations as slightly toxic or nontoxic substances with the potential anti-asthmatic and anti-allergic activity.


computer prediction; biological activity; acute toxicity; synthesis; 2-hydrazinoquinazolin-4(3H)- ones; [1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones

Full Text:



Alagarsamy V., Giridhar R., Yadav M. R. Bioorg. Med. Chem. Lett., 2005, Vol. 15, No.7, pp.1877-1880.

Alagarsamy V., Giridhar R., Yadav M. R. J. Pharm. Pharmacol., 2006. Vol. 58, No.9, pp.1249-1255.

Alagarsamy V., Meena S., Ramaseshu K. V. et al. Chem. Biol. Drug Des., 2007, Vol. 70, No.2, pp.158-163.

Alagarsamy V., Solomon V. R., Murugan M. Bioorg. Med. Chem., 2007, Vol. 45, No.12, pp.4009-4015.

Alagarsamy V., Rupeshkumar M., Kavitha K. et al. Eur. J. Med. Chem., 2008, Vol. 43, No.11, pp.2331-2337.

Alagarsamy V., Shankar D., Murugesan S. Biomed. Pharmacother., 2008, Vol. 62, No.3, pp.173-178.

Alagarsamy V., Parthiban P., Solomon V. R. et al. J. Heterocyclic Chem., 2008, Vol. 45, No.3, pp.709-715.

Alagarsamy V., Kavitha K., Rupeshkumar M. et al. Acta Pharmaceut., 2009, Vol. 59, pp.97-106.

Alagarsamy V., Sharma H. K., Parthiban P. et al. Pharmazie, 2009, Vol. 64, pp.5-9.

Gobinath M., Subramanian N., Alagarsamy V. J. Saudi Chem. Soc., 2015, Vol. 19, No.3, pp.282-286.

Gobinath M., Subramanian N., Alagarsamy V. et al. Trop. J. Pharm. Res., 2015, Vol. 14, No.2. pp.271-277.

Abdel Gawad N. M., Georgey H. H., Youssef R. M. et al. Med. Chem. Res., 2011, Vol. 20, No.8, pp.1280-1286.

Alagarsamy V., Giridhar R., Yadav M. R. et al. Indian J. Pharm. Sci., 2006, Vol. 68, No.4, pp.532-535.

Deshmukh M. B., Patil S., Patil S. S. et al. Indian J. Pharm. Sci., 2010, Vol. 72, No.4, pp.500-504.

Gobinath M., Subramanian N., Alagarsamy V. International Journal of Research in Pharmaceutical Sciences, 2012, Vol. 3, No.1, pp.146-149.

Gaudilliere B., Lavalette R., Andrianjara C. Pat. France 2792938, (2000).

Elansary A. K., Kadry H. H., Ahmed E. M. et al. Med. Chem. Res., 2012, Vol. 21, No.11, pp.3327-3335.

Березовская И. В. ХФЖ, 2003, Т. 37, №3, с.32-34.

Данильченко С. Ю., Друшляк О. Г., Коваленко С. М. ЖОрФХ, 2014, Т. 12, №3(47), с.66-73.

Saleh M. A., Abdel-Megeed M. F., Abdo M. A. et al. J. Heterocyclic Chem., 2003, Vol. 40, No.1, pp.85-92.

Filimonov D. A., Lagunin A. A., Gloriozova T. A. et al. Chem. Heterocycl. Com., 2014, Vol. 50, No.3, pp.444-457.

Филимонов Д. А., Поройков В. В., РХЖ., 2006, Т. L, №2, с.66-75.

Filimonov D. A., Poroikov V. V., in Chemoinformatics Approaches to Virtual Screening, Varnek A., Tropsha A. (Eds.), Cambridge: RSC Publishing, 2008, p.182.

Lagunin A., Zakharov A., Filimonov D. et al. Mol. Inform., 2011, Vol.30, No.2-3, pp.241-250.

GOST Style Citations


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Abbreviated key title: Ž. org. farm. hìm.

ISSN 2518-1548 (Online), ISSN 2308-8303 (Print)