The synthesis of 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes




5-(quinolin-2-yl)-1,2,4-triazole-3-thiol; 4-arylidenamino derivatives; quinaldic acid; biological activity


Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reaction
with aldehydes.
Results and discussion. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized, and a number of 4-(ethyl, aryl)idenamino derivatives were obtained on its basis.
Experimental part. Using a series of four successive reactions based on quinoline-2-carboxylic acid, 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized; its interaction with aldehydes allowed to obtain a number of 4-(ethyl, aryl)idenamino derivatives. The structure of all compounds synthesized was confrmed by IR and 1H NMR spectroscopy, as well as by elemental analysis, and their purity by thin layer chromatography.
Conclusions. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol has been synthesized. It has been found that its interaction with aldehydes leads to the formation of new 4-((ethyl, aryl)idenamino)-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiols.
Key words: 5-(quinolin-2-yl)-1,2,4-triazole-3-thiol; 4-arylidenamino derivatives; quinaldic acid; biological


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  1. Kaplaushenko, A. G. Acylation of 4-mono- and 4,5-disubstituted 1,2,4-triazol-3-thiones and data of acute toxicity of reaction products. Ukrainian biopharmaceutical journal 2014, 2, 50 – 54.
  2. Rud, A. M.; Kaplaushenko, A. G.; Samеliuk, Y. G. Synthesis of new alkylsulfonyl(sulfinyl)-1,2,4-triazole derivatives based on (3-(alkylthio)-4-R-1,2,4-thriazole-5-yl)(phenyl)methanol’s. Current issues in pharmacy and medicine: science and practice 2018, 11 (1), 23 – 28.
  3. Kaplaushenko, Т. М.; Panasenko, О. І.; Samelyuk, Y. G. Synthesis and establishment of physico-chemical constants of 2-(5-(chinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acids and their esters. Farmatsevtychnyi zhurnal 2016, 2, 53 – 59.
  4. Kaplaushenko, T. M. Synthesis, physical-chemical properties and further transformation of 5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dyhydro-3Н-1,2,4-triazole-3-thiones. Current issues in pharmacy and medicine: science and practice 2016, 2, 20 – 25.
  5. Каплаушенко, А. Г.; Книш, Є. Г.; Панасенко, О. І.; Самелюк, Ю. Г.; Кучерявий, Ю. М.; Щербак, М. О.; Каплаушенко, Т. М.; Рудь, А. М.; Гуліна, Ю. С. Практичне значення та застосування похідних 1,2,4-триазолу. Запорізький державний медичний університет: Запоріжжя, 2016.
  6. Колесник, Ю. М.; Каплаушенко, А. Г.; Книш, Є. Г.; Панасенко, О. І.; Щербак, М. О.; Самелюк, Ю. Г. Похідні 4-аміно та 3-тіо-1,2,4-триазолу як потенційні лікарські засоби; ТОВ «Карат»: Запоріжжя, 2014.
  7. Машковский, М.Д. Лекарственные средства, 15-е изд.; Новая волна: Москва, 2005.
  8. Peyton, L.R.; Gallagher, S.; Hashemzadeh, M. Triazole antifungals: a review. Drugs of Today 2015, 51 (12), 705 – 718.
  9. Sattar, A.; Ur Rehman, A.; Abbasi, M. A.; Siddiqui, S. Z.; Rasool, Sh.; Khalid, H.; Lodhi, M. A.; Khan, F. A. Synthesis, biological evaluation, and in silico study of some unique multifunctional 1,2,4-triazole acetamides. Turkish Journal of Chemistry 2018, 42 (2), 401 – 417.
  10. Kaplaushenko, A. H.; Knysh, Ye. H.; Panasenko, O. I. Search of biologically active substances among 4-mono and 4,5-disubstituted 1,2,4-triazol-3-thions and their derivatives. Pharmaceutical Review 2007, 1, 32 – 35.
  11. Kaplaushenko, A. G. The use of 1,2,4-triazole derivatives as those, that are widely used in medicine, and the creation of potential medicines based on this heterocycle. Scientific Journal of the Ministry of Health of Ukraine 2013, 3, 152 – 159.
  12. Kaplaushenko, A. G. Synthesis methods and biological activity of 1,2,4-triazol-3-thions. Ukrainian biopharmaceutical journal 2009, 4, 48 – 53.
  13. Kaplaushenko, A. G. Chemical properties of amino- and thio-derivatives of 1,2,4-triazoles. Current issues in pharmacy and medicine: science and practice 2015, 1, 101 – 106.
  14. Казицына, Л. Α.; Куплетская, Н. Б. Применение УФ-, ИК-, ЯМР- и масс-спектроскопии в органической химии. Издательство Московского университета: Москва, 1979.



How to Cite

Zozulynets D. М.; Kaplaushenko, A. G.; Korzhova, A. S. The Synthesis of 4-Amino-5-(quinolin-2-Yl)-4H-1,2,4-Triazole-3-Thiol and Its Interaction With Aldehydes. J. Org. Pharm. Chem. 2021, 19, 48-52.



Original Researches