Features of Nitration of Aromatic Aldehydes with the Difluoromethoxy Group

Authors

  • Kirill I. Petko Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, Ukraine https://orcid.org/0000-0002-2522-0128
  • Andrey A. Filatov Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Enamine Ltd., Ukraine https://orcid.org/0000-0001-7050-8131
  • Taras M. Sokolenko Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, Ukraine

DOI:

https://doi.org/10.24959/ophcj.23.285469

Keywords:

difluorometoxybenzaldehydes, nitration, ipso-substitutuion

Abstract

Nitration of aromatic aldehydes with difluoromethoxy group results in the partial ipso-substitution of the aldehyde group if difluoromethoxy group is located in the para-position to the aldehyde group. The presence of a chlorine atom in the meta-position to the aldehyde group increases the contribution of the ipso-substitution, while the presence of a chlorine atom in the ortho-position to the aldehyde group reduces it. The presence of strong donors (alkoxy groups) in the molecule eliminates the contribution of the ipso-substitution.

Supporting Agency

  • The authors received no specific funding for this work

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Published

2023-09-05

How to Cite

(1)
Petko, K. I.; Filatov, A. A.; Sokolenko, T. M. Features of Nitration of Aromatic Aldehydes With the Difluoromethoxy Group. J. Org. Pharm. Chem. 2023, 21, 3-10.

Issue

Vol. 21 No. 3 (2023)

Section

Original Researches

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