5-Трифлуорометоксизаміщена нікотинова кислота, нікотинамід і споріднені сполуки

Taras M. Sokolenko; Yurii L. Yagupolskii

doi:10.24959/ophcj.24.302435

Authors

Taras M. Sokolenko Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, Ukraine https://orcid.org/0000-0002-3944-5571
Yurii L. Yagupolskii Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Enamine Ltd., Ukraine https://orcid.org/0000-0002-5179-4096

DOI:

https://doi.org/10.24959/ophcj.24.302435

Keywords:

nicotinic acid, nicotinamide, trifluoromethoxy group, antimony trifluoride, fluorination

Abstract

A practical and convenient method for synthesizing nicotinic acid and nicotinamide with the trifluoromethoxy group in position 5 of the ring has been developed. A series of related compounds, for example, nicotinic aldehyde and nicotinic alcohol, have been synthesized. It has been shown that 3-bromo-5-trifluoromethoxypyridine is a convenient and efficient synthon for palladium-catalyzed coupling reactions. The trifluoromethoxy group has been found to be remarkably stable against hydroiodic acid in contrast to the methoxy group.

Supporting Agency

The authors received no specific funding for this work.

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