5-Trifluoromethoxy-substituted Nicotinic Acid, Nicotinamide and Related Compounds

Authors

DOI:

https://doi.org/10.24959/ophcj.24.302435

Keywords:

nicotinic acid, nicotinamide, trifluoromethoxy group, antimony trifluoride, fluorination

Abstract

A practical and convenient method for synthesizing nicotinic acid and nicotinamide with the trifluoromethoxy group in position 5 of the ring has been developed. A series of related compounds, for example, nicotinic aldehyde and nicotinic alcohol, have been synthesized. It has been shown that 3-bromo-5-trifluoromethoxypyridine is a convenient and efficient synthon for palladium-catalyzed coupling reactions. The trifluoromethoxy group has been found to be remarkably stable against hydroiodic acid in contrast to the methoxy group.

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  • The authors received no specific funding for this work.

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Published

2024-04-27

How to Cite

(1)
Sokolenko, T. M.; Yagupolskii, Y. L. 5-Trifluoromethoxy-Substituted Nicotinic Acid, Nicotinamide and Related Compounds. J. Org. Pharm. Chem. 2024, 22, 22-30.

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Original Researches