Podophyllotoxin and Aryltetralin Lignans: Methods for the Synthesis of Rings A, B, C, D

Authors

  • Francisco Flores-Hernández Laboratorio de Química Farmacéutica, Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías Universidad de Guadalajara, Mexico
  • Tania Isabel Zárate-López Laboratorio de Química Farmacéutica, Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías Universidad de Guadalajara, Mexico
  • Marco Antonio Alcaráz-Cano Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Mexico
  • Jaime Escalante Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Mexico https://orcid.org/0000-0001-5485-0244
  • José Domingo Rivera-Ramírez Laboratorio de Química Farmacéutica, Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías Universidad de Guadalajara, Mexico

DOI:

https://doi.org/10.24959/ophcj.24.308942

Keywords:

lignans, podophyllotoxin, aryltetralin-lignans, etoposide, teniposide

Abstract

Podophyllotoxin, its derivatives and structural analogues are an extensive group of aryl-tetralin-lignans of interest in pharmacology due to their promising anticancer and antitumor activity. The synthesis methods that have been proposed to date seek to resolve synthetic, stereochemical, pharmacodynamic and environmental aspects. In this review we have updated and brought together different classifications of lignan and podophyllotoxin synthesis. Transformation methods focus on the strategies used to form or functionalize rings A, B, C and D, as well as the configuration of the system of four stereogenic centers that fuse rings C and D.

Supporting Agency

  • The authors thank the Consejo Nacional de Humanidades Ciencia y Tecnología (CONAHCYT) for the funding granted to carry out this research through the Ciencia Frontera project No. 610262 called “The chemo-enzymatic synthesis of podophyllotoxin-type lignans using green chemistry bases and their evaluation as probable antitumor compounds.”

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Published

2024-11-08

How to Cite

(1)
Flores-Hernández, F.; Zárate-López, T. I.; Alcaráz-Cano, M. A.; Escalante, J.; Rivera-Ramírez, J. D. Podophyllotoxin and Aryltetralin Lignans: Methods for the Synthesis of Rings A, B, C, D. J. Org. Pharm. Chem. 2024, 22, 3-25.

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Vol. 22 No. 2 (2024)

Section

Review Articles

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