O- and N-Difluoromethylation of 2-Pyridones with Chlorodifluoromethane

Authors

DOI:

https://doi.org/10.24959/ophcj.24.312997

Keywords:

2-pyridones, difluorometylation, chlorodifluoromethane

Abstract

Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence of substituents in the pyridine ring, have been found. The possibility of obtaining difluoromethylation products at the nitrogen atom, in some cases with a preparative yield, has been investigated.

Supporting Agency

  • The authors received no specific funding for this work.

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Published

2024-11-08

How to Cite

(1)
Petko, K. I.; Filatov, A. A. O- and N-Difluoromethylation of 2-Pyridones With Chlorodifluoromethane. J. Org. Pharm. Chem. 2024, 22, 53-58.

Issue

Vol. 22 No. 2 (2024)

Section

Original Researches

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