Synthesis and Anti-inflammatory Activity of Some New 6-Aryltriazolo[3,4-b][1,3,4]thiadiazole Derivatives

Authors

DOI:

https://doi.org/10.24959/ophcj.24.321751

Keywords:

[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole, anti-inflammatory activity, cyclooxygenase, docking

Abstract

A series of 6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been synthesized. Their anti-inflammatory activity has been studied in vivo in a carrageenan model of the paw inflammatory edema in rats. 3-(2-Fluorophenyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (3c) and 3-(2-fluorophenyl)-6-(4-methoxy-phenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (3d) have been identified as hit compounds with the anti-exudative activity. The crucial role of the fluorine atom in the anti-inflammatory activity has been determined, which value considerably correlates with the calculated values of lipophilicity and solubility.

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  • The author received no specific funding for this work.

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Published

2024-12-07

How to Cite

(1)
Myrko , I. I. Synthesis and Anti-Inflammatory Activity of Some New 6-Aryltriazolo[3,4-b][1,3,4]thiadiazole Derivatives. J. Org. Pharm. Chem. 2024, 22, 17-24.

Issue

Vol. 22 No. 4 (2024): Issue in Progress

Section

Original Researches

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