An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols

Authors

  • Oleksandr V. Borysov Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Enamine Ltd., Ukraine https://orcid.org/0000-0003-0360-9295
  • Dmytro P. Bohdan Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, Ukraine

DOI:

https://doi.org/10.24959/ophcj.25.324523

Keywords:

pyridine, thiols, thiobenzoic acid, chromatography, hydrolysis

Abstract

A practical and convenient method for the synthesis of pyridine-3-thiols using substituted 3-iodopyridines as starting compounds has been developed. Based on the use of thiobenzoic acid as a sulfur donor in a two-step procedure, this approach made it possible to synthesize a number of pyridine-3-thiols with F, Cl, Br, CH3, OCH3 substituents at various positions of the pyridine ring. The procedure presented gives high yields of the target products with a purity of 95% and is suitable for synthesis in tens of grams.

Supporting Agency

  • The authors received no specific funding for this work.

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Published

2025-05-05

How to Cite

(1)
Borysov, O. V.; Bohdan, D. P. An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols. J. Org. Pharm. Chem. 2025, 23, 43-48.

Issue

Vol. 23 No. 1 (2025)

Section

Original Researches

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