Annelation of the 1,2,4-Triazine Core to 2,3-Benzodiazepine

Authors

DOI:

https://doi.org/10.24959/ophcj.25.327856

Keywords:

2,3-benzodiazepine, α-ketoester, 1,2,4-triazine, annelation

Abstract

A one-pot, stepwise method for the annelation of the 1,2,4-triazine core to the seven-membered 2,3-benzodiazepine ring via the interaction of the corresponding 2,3-benzodiazepin-1-yl- or 2,3-benzodiazepin-4-ylhydrazines with α-ketoesters has been developed. It has been found that a stepwise formation of an azomethine intermediate followed by solvent replacement and subsequent cyclization enables the desired compounds to be obtained in high yields. Derivatives of a new heterocyclic system of [1,2,4]triazino[3,4-a][2,3]benzodiazepine have been synthesized.

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  • The authors received no specific funding for this work.

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Published

2025-09-17

How to Cite

(1)
Bohdan, N. M.; Shuvakin, S. I.; Nechaieva, D. S.; Suikov, S. Y.; Bohza, S. L. Annelation of the 1,2,4-Triazine Core to 2,3-Benzodiazepine. J. Org. Pharm. Chem. 2025, 23, 22-27.

Issue

Vol. 23 No. 3 (2025)

Section

Original Researches

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