One-pot synthesis of the substituted imidazolidin-2-ones with participation of thiobarbituric acid, ureas and arylglyoxals

Authors

  • N. M. Kolos V.N.Karazin Kharkiv National University, Ukraine
  • L. L. Zamigaylo DNU "NTK" Institute of Single Crystals "of the National Academy of Sciences of Ukraine, Ukraine
  • N. V. Chechina V.N.Karazin Kharkiv National University, Ukraine

DOI:

https://doi.org/10.24959/ophcj.13.742

Keywords:

imidozoline-2-ones, one-pot synthesis, tautomerism, thiobarbituric acid, arylglyoxals, ureas

Abstract

Derivatives of imidozoline-2-ones containing the pyrimidinthionic moiety in position 4 have been synthesized by three-component one-pot condensation of thiobarbituric acid, arylglyoxal hydrates and ureas. It has been found that these compounds exist in the solution of DMSO-d6 as a mixture of two tautomeric forms: for products obtained from N-substituted ureas the imidazolidin form predominates; and in the case of urea the imidazolidin and imidazolin forms are present in the ratio of 1:1.

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Published

2013-09-10

How to Cite

(1)
Kolos, N. M.; Zamigaylo, L. L.; Chechina, N. V. One-Pot Synthesis of the Substituted Imidazolidin-2-Ones With Participation of Thiobarbituric Acid, Ureas and Arylglyoxals. J. Org. Pharm. Chem. 2013, 11, 72-77.

Issue

Vol. 11 No. 3(43) (2013)

Section

Original Researches

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Copyright (c) 2013 National University of Pharmacy

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