Synthesis and alkylation of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-ones

Authors

  • S. V. Vlasov National University of Pharmacy, Ukraine
  • S. M. Kovalenko National University of Pharmacy, Ukraine
  • V. P. Chernykh National University of Pharmacy, Ukraine
  • K. Yu. Krolenko National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/ophcj.15.822

Keywords:

thiophene, pyrimidine, imidazole, alkylation

Abstract

The one-step method for preparation of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-ones by interaction of 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid with ortho-pnenylediamines using 1,1’-carbonyldiimidazole as a coupling-reagent has been developed. The procedure proposed allows to obtain easily the target products using common reagents and solvents; and it also requires the simple isolation methods. The selectivity of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-one interaction with benzyl chlorides in DMF – K2CO3 conditions has been studied using the NOESY spectroscopic method and alternative synthetic approaches; it has been determined that the reaction occurs at position 3 of the thieno[2,3-d] pyrimidine system. The study of the antimicrobial activity by the agar diffusion method for the compounds obtained has shown that 6-(1H-benzimidazol-2-yl)-3-benzyl-5-methylthieno[2,3-d]pyrimidin-4(3H)-ones reveal the antimicrobial activity against the strains of Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa; while the compound with unsubstituted position 3 appeared to be inactive against these strains of microorganisms. However, this compound exhibited the higher inhibitory activity against the Candida albicans fungi.

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Published

2015-06-10

How to Cite

(1)
Vlasov, S. V.; Kovalenko, S. M.; Chernykh, V. P.; Krolenko, K. Y. Synthesis and Alkylation of 6-(1H-Benzimidazol-2-Yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-Ones. J. Org. Pharm. Chem. 2015, 13, 30-34.

Issue

Vol. 13 No. 2(50) (2015)

Section

Original Researches

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