Development of quality control methods for the substance 4-benzyl-1-{4-[4-(4-methoxyphenyl)- piperazin-1-yl]-4-oxobutyl}[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one

Authors

  • S. Yu. Danylchenko National University of Pharmacy, Ukraine
  • S. M. Kovalenko V.N.Karazin Kharkiv National University, Ukraine
  • S. M. Gubar National University of Pharmacy, Ukraine
  • I. S. Zhuk V.N.Karazin Kharkiv National University, Ukraine
  • I. O. Mariutsa National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/ophcj.18.941

Keywords:

methods of quality control, qualitative and quantitative determination, derivatives of [1, 2, 4] triazolo[4, 3-a]quinazolin-5(4H)-ones, antimalarial activity

Abstract

Aim. To develop the project of quality control methods for the leader compound among derivatives of [1,2,4]triazolo[4,3-a]quinazoline-5(4H)-ones, namely 4-benzyl-1-{4-[4-(4-methoxyphenyl)-piperazin-1-yl]-4-oxobutyl}-[1,2,4]triazolo[4,3-a]quinazolin-(4H)-one as a promising antimalarial agent for further in-depth studies.
Experimental part. Taking into account the requirements of the general monograph “Substances for pharmaceutical use” it has been proposed to include the following indicators to the project of quality control methods: description, solubility, identification (using infrared and ultraviolet spectroscopy), related impurities (liquid chromatography method), the loss on drying, the residue on ignition, residual organic solvents, microbiological purity, assay by potentiometric titration with chloric acid in acetic acid.
Conclusions. The methods of quality control of a leader compound – 4-benzyl-1-{4-[4-(4-methoxyphenyl)- piperazin-1-yl]-4-oxobutyl}[1,2,4]-triazolo[4,3-a]quinazolin-(4H)-one have been developed.

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References

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Published

2018-06-08

How to Cite

(1)
Danylchenko, S. Y.; Kovalenko, S. M.; Gubar, S. M.; Zhuk, I. S.; Mariutsa, I. O. Development of Quality Control Methods for the Substance 4-Benzyl-1-{4-[4-(4-Methoxyphenyl)- Piperazin-1-Yl]-4-oxobutyl}[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-One. J. Org. Pharm. Chem. 2018, 16, 49-59.

Issue

Vol. 16 No. 2(62) (2018)

Section

Original Researches

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