The synthesis, study of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridyn-3-yl)-(alkyl, heteryl)methanimines and their derivatives

Authors

  • T. V. Ignatova Zaporizhzhia State Medical University, Ukraine
  • A. H. Kaplaushenko Zaporizhzhia State Medical University, Ukraine
  • Yu. S. Frolova Zaporizhzhia State Medical University, Ukraine

DOI:

https://doi.org/10.24959/ophcj.18.956

Keywords:

1, 2, 4-triazole, pyridine, synthesis, physicochemical properties

Abstract

In the pharmaceutical practice directly related to the search of biological active substances and their introduction into medicine or veterinary it is generally recognized that a successful choice of the research object is a prerequisite for a positive final outcome to create original effective and low-toxic drugs. At present, derivatives of 1,2,4-triazoles containing pyridine deserve special attention. That is why the synthesis and study of physicochemical properties of new compounds, which contain 1,2,4-triazole and pyridine rings, are important tasks of modern synthetic and pharmaceutical chemistry.

Aim. To study the reactions associated with formation and transformation of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines and their recovery, study physicochemical properties of new compounds synthesized.

Materials and methods. 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heter-yl)methanimines were obtained by the mixture from 6-(5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-amine and aldehydes. The synthesis was carried out in the acetic acid medium. The mixture was kept at room temperature for 6 h. 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines were reduced in the 1,4-dioxane medium. As a reducing agent sodium borohydride was used.

Results and discussion. As a result of synthetic transformations 17 new compounds have been obtained, the structure of the compounds synthesized has been confirmed by modern complex of physicochemical methods of analysis (IR-spectrophotometry, elemental analysis), and their individuality has been proven on an Agilent 1260 Infinity HPLC high-performance liquid chromatograph equipped with an Agilent 6120 mass spectrometer.

Conclusions. The preparative method for the synthesis of 6-((5-phenethyl-4-R-1,2,4-triazole-3-ylthio)pyridine-3-yl)-(alkyl-, heteryl)methanimines and 6-(5-phenethyl-4-R-1,2,4-triazole-3-ylthio)-N-(alkyl-, heteryl)pyridine-3-amines has been developed.

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References

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Published

2018-12-14

How to Cite

(1)
Ignatova, T. V.; Kaplaushenko, A. H.; Frolova, Y. S. The Synthesis, Study of 6-(5-Phenethyl-4-R-1,2,4-Triazole-3-ylthio)pyridyn-3-Yl)-(alkyl, heteryl)methanimines and Their Derivatives. J. Org. Pharm. Chem. 2018, 16, 34-39.

Issue

Vol. 16 No. 4(64) (2018)

Section

Original Researches

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