Recent advances in the asymmetric functionalization of N-(tert-butylsulfinyl)polyfluoroalkyl imines

Authors

DOI:

https://doi.org/10.24959/ophcj.25.321224

Keywords:

tert-butylsulfinyl, polyfluoroalkyl imines, asymmetric synthesis, aldimines, ketimines, stereoselectivity

Abstract

The review covers the latest achievements in the application of N-(tert-butylsulfinyl)polyfluoroalkyl imines in the asymmetric synthesis and summarizes stereochemical observations of their behavior in different types of reactions (reduction of the C=N bond, addition reactions with organometallic reagents, C-H acids, etc.). Fluorinated N-(tert-butylsulfinyl) imines are convenient substrates for obtaining enantiomerically enriched derivatives of polyfluoroalkyl amines, amino alcohols, amino acids, and heterocyclic systems. In recent decades, various approaches to their functionalization have been proposed. With this in mind, important aspects of their reactivity, regio- and stereochemistry have been systematized in this paper.

Supporting Agency

  • The work was supported by the National Academy of Sciences of Ukraine (grant No. 0124U002052).

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Published

2025-04-11

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(1)
Cherednichenko, A. S.; Rassukana, Y. V. Recent Advances in the Asymmetric Functionalization of N-(tert-butylsulfinyl)polyfluoroalkyl Imines. J. Org. Pharm. Chem. 2025, 23, 3-22.

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Vol. 23 No. 2 (2025)

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Review Articles

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