Vol. 23 No. 2 (2025): Issue in Progress

The review covers the latest achievements in the application of N-(tert-butylsulfinyl)polyfluoroalkyl imines in the asymmetric synthesis and summarizes stereochemical observations of their behavior in different types of reactions (reduction of the C=N bond, addition reactions with organometallic reagents, C-H acids, etc.). Fluorinated N-(tert-butylsulfinyl) imines are convenient substrates for obtaining enantiomerically enriched derivatives of polyfluoroalkyl amines, amino alcohols, amino acids, and heterocyclic systems. In recent decades, various approaches to their functionalization have been proposed. With this in mind, important aspects of their reactivity, regio- and stereochemistry have been systematized in this paper.

Pd nanoparticles were deposited on two different grades of activated carbon – NORIT and CAW. In addition, these carbons were pre-treated with HNO₃ or covered by polyaniline, and these modified carbons were used as carriers for the Pd deposition. The resulting materials were tested as catalysts for the hydrogenation of quinoline. The best-performing samples were further tested in the hydrogenation of 4-methylquinoline. The structural features of carriers and catalysts were elucidated by the N₂ adsorption studies. The grade of activated carbon was found to be a key factor controlling its performance, and the effect of the surface modification was negligible.

The interaction of substituted nitrobenzenes containing activated halogen atoms (fluorine or chlorine) and the difluoromethoxy group with an aqueous solution of ammonia at high pressure and temperature of 80 - 160 °C was studied. It has been found that under the conditions studied, the difluoromethoxy group can be replaced by the amino group as a pseudohalogen. It has been shown that the reactivity of the difluoromethoxy group in the same positions is lower than that of the fluorine atom, but significantly higher than that of the chlorine atom.