Žurnal organičnoï ta farmacevtičnoï himiï

«Journal of Organic and Pharmaceutical Chemistry» was begun to publish in 2003 and is regarded as assignee of «Fìzìologìčno aktivnì rečovini» journal that was founded in 1966. The journal was established by National Academy of Sciences (NAS) of Ukraine in cooperation with Institute of Organic chemistry of NAS of Ukraine and National University of Pharmacy (state registration certificate КВ №23086-12926ПР, 05.01.2018, ISSN 2308-8303 (Print); ISSN 2518-1548 (Online)). The journal is included in the List of specialized scientific editions of Ukraine for publishing results of PhD works in the fields of chemistry and pharmacy approved by the Ministry of Education and Science of Ukraine (decree of the Ministry of Education and Science of Ukraine №515, 16.05.2016).

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Greeting to the rector of National University of Pharmacy A. A. Kotvitska on Day of pharmaceutical worker of Ukraine


Dear colleagues! 

I sincerely congratulate you on the Day of Pharmaceutical Worker of Ukraine!

This year we celebrate the 20th anniversary of our professional holiday –
holidays of people who have dedicated themselves to Pharmacy. The persistent and painstaking work of each pharmaceutical worker is the key to the health and well-being of people. Commitment to the noble cause, professional experience and deep knowledge are valued by the Ukrainian society and recognized at the state level. Anniversary is not just a holiday, it gains our relentless forward, the common path – successful and productive. Step by step, over the years, we have had many hopes and ideas for developing the healthcare pharmaceutical sector.

With you and with your support and participation, we hosted four National Congresses of Pharmacists of Ukraine, each of which was valuable to the pharmaceutical community: our professional holiday, state honorary titles were founded, the Code of Ethics of the Pharmaceutical Worker of Ukraine was adopted; such exclusive editions as Pharmaceutical Encyclopedia, Rx index are presented – Handbook of Medicinal Equivalence, State Pharmacopoeia of Ukraine; achievements of the national pharmaceutical industry, experience of integration with the European space are presented; the essential needs of the industry and the basic conceptual directions of development of the pharmaceutical sector of the healthcare sector are considered.

Today, we are witnesses and direct participants in the progressive development of domestic pharmacy and the significant positive changes that are taking place in it. Of course, there are problems, unresolved issues, expectations…, but together we are steadfastly and confidently following our path – service to the ideals of goodness and justice, loyalty to the chosen cause, training of highly qualified specialists and education of the nation's intellectual elite generation.

Dear colleagues, partners, friends, accept the warmest wishes of good health, personal happiness, inexhaustible energy and enthusiasm in all your good deeds. May peace and harmony reign in your home, goodness in heart, and wisdom and prudence in deeds. May destiny fill every new day with pleasant events, giving joy of life, irreproachable luck, faithful and reliable friends! I am convinced that your professionalism and humanity, vital knowledge and experience, kindness and humanity will continue to contribute to the development of modern pharmacy!


With best regards,

Rector of the National University of Pharmacy,

Chairman of the organizing committee

Alla Anatoliivna Kotvitska

Posted: 2019-05-17
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Vol 17, No 3(67) (2019)

Table of Contents

The search for potential inhibitors of protein kinase Pim-1 among new amides of 1,2,4-triazolo[4,3-a]pyridine-3-metanamin with the 1,2,4-oxadiazol cycle in position 7 and 8 PDF (Українська)
V. R. Karpina, S. M. Kovalenko, O. V. Zaremba, O. V. Silin, V. V. Ivanov, S. S. Kovalenko, T. Langer 5-14
Synthesis and antioxidant properties of novel thiazolo[4,5-b]pyridine-2-ones PDF (Українська)
T. I. Chaban, Yu. E. Matiychuk, V. V. Ogurtsov, I. G. Chaban, V. S. Matiychuk 15-20
Synthesis and the biological activity of bis-mefenamidocalixarene PDF (Українська)
N. M. Chalenko, R. V. Rodik, G. O. Syrova 21-25
The study of the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method PDF (Українська)
S. V. Vlasov, S. M. Kovalenko, T. P. Osolodchenko, V. S. Vlasov 26-30
The acid-base properties of 2-(benzoylamino)(1-R-2-oxoindolin-3-ylidene)acetic acids PDF (Українська)
S. V. Kolisnyk, O. M. Svechnikova, O. O. Altukhov, O. V. Kolisnyk, O. F. Vynnyk 31-34
Development and validation of the enzymatic kinetic photometric procedure for determination of residual quantities of dequalinium chloride on the surface of the pharmaceutical equipment PDF (Українська)
M. Ye. Blazheyevskiy, O. V. Kovalska, Ye. O. Tsapko, D. D. Shapovalenko 35-43
The comparative quantum chemical study of the epoxidation reaction mechanism of eugenol and isoeugenol with peracetic and perbenzoic acids PDF
O. M. Agafonov, S. I. Okovytyy, M. Ye. Blazheyevskiy 44-50
Development and validation of the HPLC-procedure for the quantitative determination of isosorbide dinitrate in matrix granules PDF (Українська)
D. S. Oleynikov, A. G. Kaplaushenko 51-58